Once Koch established the methods to grow pure cultures of bacteria like tuberculosis and anthrax, he demonstrated for the first time that microbes can cause diseases, a feat that earned him the 1905 Nobel Prize in Physiology or Medicine.
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（三）未经许可，擅自经营按照国家规定需要由公安机关许可的行业的。
但是，奧爾代也指出，由於關稅普遍適用，有一件事是確定的：外國產品在美國的價格普遍會更高。