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O'Farrell said his weight loss with the drug was "almost instant" and that, as well as losing more than five stone (34kg) so far, he has more energy and has been able to exercise for the first time in years.
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The 80386 introduced Virtual 8086 (V86) mode -- allowing real-mode DOS programs to run inside protected mode under OS supervision. While not full virtualization in the modern sense, V86 was the first practical hardware-assisted mechanism on x86 for running legacy software in a protected environment -- used widely in Windows 3.x and Windows 9x.
More concept art for the project.